Hubert Serve Selected Research

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

12/2021	Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation.
12/2019	Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.
1/2018	Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation.
9/2012	Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation.
8/2012	Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.
9/2011	High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation.
2/2011	Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma.
11/2010	Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
2/2007	DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.

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Hubert Serve Research Topics

Disease

73	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2022 - 07/2002
44	Neoplasms (Cancer) 01/2022 - 07/2002
26	Leukemia 01/2020 - 07/2002
9	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2021 - 02/2007
9	Infections 11/2020 - 04/2005
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2010 - 02/2003
7	Neoplasm Metastasis (Metastasis) 04/2010 - 09/2003
5	Multiple Myeloma 01/2022 - 01/2018
5	Neutropenia 01/2022 - 04/2009
5	Burkitt Lymphoma (Burkitt's Lymphoma) 10/2020 - 02/2011
4	Disease Progression 01/2022 - 02/2015
4	Lymphoma (Lymphomas) 01/2019 - 10/2004
4	Philadelphia Chromosome 01/2018 - 08/2012
4	Testicular Neoplasms (Testicular Cancer) 03/2005 - 02/2003
3	Acute Promyelocytic Leukemia 12/2021 - 03/2008
3	Sepsis (Septicemia) 10/2021 - 03/2019
3	Lung Neoplasms (Lung Cancer) 01/2021 - 09/2003
3	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2016
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2020 - 07/2003
3	Fever (Fevers) 11/2020 - 12/2015
3	Hematologic Diseases (Blood Diseases) 03/2019 - 02/2007
2	Colonic Neoplasms (Colon Cancer) 01/2021 - 03/2005
2	Exanthema (Rash) 11/2020 - 12/2015
2	Residual Neoplasm 10/2020 - 09/2011
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2020 - 12/2018
2	Seminoma 01/2019 - 02/2003
2	Obesity 01/2019 - 07/2016
2	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 01/2019 - 02/2003
2	Vesicular Stomatitis 01/2015 - 05/2005
2	Hematologic Neoplasms (Hematological Malignancy) 10/2011 - 08/2007
2	Carcinoma (Carcinomatosis) 03/2005 - 02/2003
2	Carcinogenesis 03/2005 - 02/2003
2	Sertoli Cell-Only Syndrome 02/2003 - 08/2002
1	Thrombocytopenia (Thrombopenia) 02/2022
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 02/2022
1	Hypoxia (Hypoxemia) 01/2022
1	Agammaglobulinemia (Hypogammaglobulinemia) 01/2022
1	Pathologic Complete Response 01/2022
1	COVID-19 01/2022
1	Reinfection 01/2022

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2002
10	Phosphotransferases (Kinase)IBA 02/2016 - 02/2004
9	Messenger RNA (mRNA)IBA 01/2022 - 07/2002
9	Biomarkers (Surrogate Marker)IBA 01/2019 - 02/2007
9	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2012 - 04/2003
8	Pharmaceutical PreparationsIBA 01/2020 - 11/2003
7	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2019 - 03/2005
6	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2020 - 04/2009
5	Cyclin A1IBA 08/2007 - 08/2002
4	ProteomeIBA 01/2022 - 02/2015
4	Azacitidine (5 Azacytidine)FDA Link 01/2021 - 01/2012
4	Sorafenib (BAY 43-9006)FDA Link 10/2020 - 06/2012
4	fms-Like Tyrosine Kinase 3IBA 10/2020 - 01/2005
4	CytokinesIBA 12/2019 - 08/2012
4	Transcription Factors (Transcription Factor)IBA 01/2017 - 04/2004
4	tyrosine receptor (receptor, tyrosine)IBA 09/2008 - 02/2004
3	midostaurinIBA 01/2021 - 01/2006
3	Tyrosine Kinase InhibitorsIBA 11/2020 - 01/2017
3	DNA (Deoxyribonucleic Acid)IBA 12/2019 - 02/2007
3	Small Interfering RNA (siRNA)IBA 01/2019 - 03/2008
3	Imatinib Mesylate (Gleevec)FDA Link 03/2011 - 09/2008
3	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA 06/2010 - 12/2004
3	CyclinsIBA 04/2005 - 09/2003
2	AntibodiesIBA 01/2022 - 01/2017
2	BNT162 VaccineIBA 01/2022 - 01/2022
2	venetoclaxIBA 12/2021 - 11/2021
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2021 - 01/2021
2	Decitabine FDA Link 01/2021 - 01/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 11/2020
2	Syk KinaseIBA 11/2020 - 05/2013
2	RNA (Ribonucleic Acid)IBA 12/2019 - 01/2019
2	NucleophosminIBA 10/2019 - 03/2016
2	Vancomycin FDA LinkGeneric 03/2019 - 07/2018
2	Histone MethyltransferasesIBA 01/2017 - 06/2014
2	Histones (Histone)IBA 03/2012 - 11/2010
2	ChromatinIBA 11/2010 - 03/2008
2	Retinoic Acid Receptor alphaIBA 06/2010 - 04/2004
2	S100 Proteins (S 100 Protein)IBA 01/2009 - 08/2004
2	ErbB Receptors (EGF Receptor)IBA 12/2005 - 03/2005
2	Sunitinib (Sutent)FDA Link 02/2005 - 11/2003
1	Fibrinogen (Factor I)FDA Link 02/2022
1	isocitric acid (isocitrate)IBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	asparaginylendopeptidase (legumain)IBA 01/2022
1	Immunomodulating AgentsIBA 01/2022
1	Immunoglobulin M (IgM)IBA 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Proteasome InhibitorsIBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	Cysteine Proteases (Cysteine Protease)IBA 01/2022

Therapy/Procedure

27	Therapeutics 08/2022 - 05/2002
16	Drug Therapy (Chemotherapy) 08/2022 - 08/2004
11	Stem Cell Transplantation 01/2022 - 09/2011
7	Induction Chemotherapy 02/2022 - 01/2019
7	Hematopoietic Stem Cell Transplantation 10/2020 - 10/2011
5	Transplantation 01/2019 - 06/2010
2	Consolidation Chemotherapy 08/2022 - 08/2012
2	Cell Transplantation 07/2018 - 03/2016
1	Aftercare (After-Treatment) 08/2022
1	Platelet Transfusion (Blood Platelet Transfusions) 02/2022